Combined alpha- and beta-adrenoceptor blockade with labetalol in hypertension.

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Combined alpha- and beta-adrenoceptor blockade with labetalol in hypertension.

The antihypertensive effect of labetalol, a new alpha- and beta-adrenoceptor inhibiting agent, was studied in 20 patients in a double-blind crossover trial. A dose of 300 mg daily reduced blood pressure only moderately in the supine position, though in the sitting and standing positions the effect was more pronounced. A dose of 600 mg daily produced statistically significant and clinically rele...

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Selective and Nonselective Beta-adrenoceptor Blockade in Hypertension: Responses

The hypertensive response to the infusion of epinephrine is exaggerated in subjects treated with noncardioselective ,B-adrenergic antagonists, but not in subjects given cardioselective agents. In this study, we sought to determine whether the same holds true when hypertensive patients treated with these drugs are subjected to acute physiologic stress. According to a randomized crossover protoco...

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Beta-adrenoceptor blockade and anesthesia

A potential for impaired cardiovascular performance among anesthetized patients due to preoperative treatment with propranolol was considered based on clinical observation of sudden, irretractable cardiac failure in five patients. As a result, a recommendation to terminate beta-adrenoceptor therapy prior to general anesthesia was advanced. During the ensuing decade many clinical researchers sou...

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Haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone in patients with coronary heart disease.

The acute haemodynamic effects of beta-blockade with propranolol and combined alpha-blockade and beta-blockade with labetalol were compared in a randomised study in 12 patients with coronary artery disease proved by angiography. Propranolol induced significantly greater depression of left ventricular function both at rest and during exercise than labetalol. This difference was probably attribut...

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Alpha- and beta-adrenoceptor antagonists.

Antagonists acting on the betaor alphaadrenoceptors are used widely in medicine and in anaesthesia. The major indications for betaadrenoceptor blockade are coronary artery disease and arterial hypertension, while those for alphaadrenoceptor blockade include arterial hypertension, paroxysmal hypertension and chronic cardiac failure. The adrenoceptor antagonists interfere with important regulator...

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ژورنال

عنوان ژورنال: BMJ

سال: 1976

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.6017.1046